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Abstract
The high prevalence of liver diseases such as chronic hepatitis &
cirrhosis underscores the need for efficient & cost-effective treatments.
The objective of this study is to assess the effects of licorice & silymarin
as protective agents and compare their effects on CCL4 induced liver
fibrosis in rats. protective mechanisms of silymarin & licorice were
examined at 4 & 8 weeks. liver tissues were examined histopathologically
and immunohistochemically for detection of alpha - SMA and NF-KB.
There were improvement in licorice treated group more than that of
silymarin treated group.
Key Words : CCL4 - alpha-SMA - NF-KB - Silymarin -
Licorice