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Abstract
Results: Thirty adult patients suffering from rheumatoid arthritis
(RA) were included in this study.Their ages ranged between 27 and
63 years old with a mean of 44.7±10.2 years. They were twenty-two
female patients with age ranged between 27 and 63 years old with a
mean of 41.7±9.8 years. and eight male patients with age ranged
between 28 and 62 years old with a mean of 56.6±4.2 years.
Modified HAQ was ranged between zero and 2.5 with a mean of 0.8
±0.549. Disease activity of RA patients was examined according to
both Mallya and Mace index ( Mallya and Mace, 1981) and also
Simplified Disease Activity Index (SDAI) ( Smolen et al., 2003) and
were found to have mostly from mild to moderate disease activity.
Physical activity score was ranged from 0 with a maximum of 2.
Triceps skin fold thickness (TSF) ranged between 8mm and 39mm
with a mean of 21.7 ±8.3. Body mass index (BMI) ranged between
20.3 and 43.2 with a mean of 27.97 ±5.4. Regarding to their
percentage of body fat , it ranged between 17% and 48% with a mean
of 31.66 ±7.2.
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IGF-1 was ranged between 60 and 376 ng/ml with a mean of 165
±84.5 ng/ml.
All the patients and healthy controls were matched according to their
sex and age. Patients showed a low level physical activity and
exercise with (p <0.001), a high % body fat (p = 0.009) and lower
levels of IGF-1 with (p =0.04) in both patient’s groups when
compared to the control group .
% of body fat was highest in non –RA group with a mean of
37.2±8.1%, followed by the control group with a mean of
32.28±6.7% and was lowest in RA group with a mean of 31.6±7.2%.
Also, IGF-I was highest in control group with a mean of 213±53
ng/ml, followed by the non –RA group with a mean of 201±75
ng/ml and was lowest in RA group with a mean of 165±84 ng/ml.
The lowest physical activity score was in non –RA group ,then the
RA group and higher scores in the control group.
In comparisons done between one group versus each of the two
groups; When The RA group was compared to both the non RA
group and the control group in relation to IGF-1 it showed a
significant values with (P=0.04) and ( P=0.03) respectively. Physical
activity score was of significant value inbetween all groups with ( P
< 0.01) .Percentage of body fat was of significant value (P=0.004)
between the RA group and Non RA group but no significant values
were detected between the RA group and the control group (P= 0. 8).
Also no significant relations were detected when assessing disease
activity in rheumatoid arthritis using multivariate Mallya and Mace
disease activity index or Simplified disease activity index (SDAI) in
relation to IGF-I.
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When correlation was done between detailed physical activity
score as being assessed by Physical activity scale score (Jackson
and Ross,1992), a significant positive value was detected with IGFI
( P= 0.04) in our RA patients