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Abstract
Fifty healthy white New Zeeland male rabbits of 30 days age were
divided into eight groups to study the effects of acute poisoning, (Exp. I,
groups 1-4) and chronic poisoning (Exp. H, groups, 5-8), on the
hematological and biochemical parameters and correlate them with the
histopathological changes in the liver and kidneys. The role of CaNar
EDTA in the treatment of acute poisoning and the preventive action of
zinc against the chronic poisoning were evaluated.
Gp. (1) was kept as healthy control for Exp. (I). Gp. (2) was daily
given lead acetate (1/2 LD50) orally via stomach tube for 8 days. Gp. (3)
was intravenously injected with CaNa2EDTA by the dose of 75 mg/kg
B.wt. for 3 successive days followed by 2 days without treatment then
other 3 days with editate treatment. Gp. (4) was given lead acetate like
gp. (2) followed by CaNa2EDTA as in gp. (3). Tissues were collected and
blood samples were obtained from the marginal ear vein on the 9th day
from the beginning of the experiment in gps. (2 & 3) and on the 1 ih day
(gps. 1 & 4).
Gp. (5) was kept as healthy control for expo H. Gp. (6) was daily
given lead acetate (1/5 LD50), orally via stomach tube for 60 days.