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Abstract
Women with epilepsy face a host of challenges, including
reproductive health disturbances. This study was designed to assess the
frequency of reproductive health disturbances in epileptic females,
examining the possible relationship between these disturbances and the
different epilepsy types or the use of different AEDs. Subjects included
81 epileptic females aged 12 to 46 years, who were not receiving
hormones; and 12 healthy age matched female volunteers. Menstrual
history and trans-abdominal ovarian ultrasound were obtained. Endocrine
variables were measured during the follicular phase as well as the luteal
phase progesterone. A significant increase in seizure frequency was
detected in patients with menstrual irregularities compared with those
without . Moreover, patients on polytherapy had a statistically significant
higher percentage of anovulation compared with those on monotherapy.
Regarding the endocrine variables, there was a statistically significant
higher values of follicular estrogen among patients (either treated or
untreated) compared with the controls, and lower values of follicular
progesterone among the treated patients compared with the untreated
ones and the controls. In conclusion, polytherapy has a hazardous effect
on the ovulatory function of WWE, although a significant differential
effect of a specific antiepileptic drug or a specific epilepsy type on
patients′ reproductive functions could not be proved.