الفهرس | Only 14 pages are availabe for public view |
Abstract Parvovirus B19 DNA was discovered in 1975 and is now recognized as causing erythema infectiosum, non-immune hydrops fetalis, and fetal death. Maternal B19 infection usually does not result in fetal disease or death. Although some cases of hydrops appear to resolve spontaneously, in others, the prognosis for the fetus is grave. It is difficult to diagnose fetal infection, so a rapid test to detect the intrauterine presence of human parvovirus B19 would add to the clinical tools used in the evaluation of intrauterine infection and aid the clinician in management decisions (e.g., transfusion of hydropic fetuses). Some investigators have described the use of PCR for amplifying B19 DNA sequence in clinical materials. |