الفهرس | Only 14 pages are availabe for public view |
Abstract Carnitine is naturally occurring hydrophilic amine acid derivative, produced endogenously in the liver and kidney and derived from meat and dairy products in the diet(Scaglia,2002). Carnitine is essential for long chain fatty acid oxidation . Fatty acids cannot penetrate the inner mitochondrial matrix and enter the mitochondrial membrane to undergo oxidation unless they transported across the inner membrane by a carrier process involving carnitine (Fuller and Hoppel,1983). As The synthesis of Carnitine is performed in the liver ,subnormal plasma carnitine concentrations are expected in patients with liver disease specially cirrhotic patients and therefor causing secondary carnitine deficiency (Selimoglu et al.,2001). |