الفهرس 
Ultrastructural features of normal liverOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus infection may cause a benign , asympto-matic disorder with an indolent course but it may cause progressive liver disease , cirrhosis and primary liver cancer .
Several viral factors , including the level of viraemia , hepatitis C virus genotype , and degree of viral diversity , may also affect the state of progression ( Dusheiko et al., 1996) .
HCV viraemia levels are not associated with the severity of liver histology , duration of disease or the source of hepatitis (Hayashi et al ., 1996 and Calabress et al., 2000 ).
The aim of this work is to study the ultrastructural changes of the liver in HCV infection .
Our study included fifty patients with chronic hepatitis C underwent liver biopsy ( 41male and 9 female ) ranging in age from 25 to 65 years at the time of liver biopsy with ( mean ± standard deviation : 45.06 ± 10.8 ). ALT ( mean ± standard deviation: 90.5 ± 50.2 and
AST ( mean ± standard deviation: 66.0 ± 35.3 ). Prothrombin concentration ( mean ± standard deviation: 76.5 ± 10.8 ). HCV RNA ( mean ± standard deviation: 11.9 ± 12.8 ). Four of the fifty needle biopsies were repeated.
We using Knodell score and modified histological activity index ( HAI ) ( Ishak et al., 1995 )
We divided our patients to four groups according to changes found by light microscopy :
Group (A): Minimal chronic active hepatitis with histological activity index(HAI) grading (1– 3) and histological stage ( 0 – 1).
Group (B): Mild chronic active hepatitis with histological activity index ( HAI ) grading ( 4 - 8 ) and staging (2)
Group (C) : Moderate chronic active hepatitis with histological activity index (HAI) grading (9-12) and staging 3.
Group (D): Sever chronic active hepatitis with histological activity index (HAI) grading (13-18) and staging 4 .