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Abstract
Our assay aimed to asses the most recent tumor markers of prostate cancer. Discussion of their types, role in diagnosis, role in staging, and disease follow up.
Discovery of molecular derivatives of PSA and new Kallikrein markers has improved prostate cancer detection. Application of various PSA derivatives, although improving sensitivity, risks impairing specificity.
Early detection when cancer remains confined to the prostate will not only improve cure rates but also decreases the mortality from this disease.
The concept of measuring the proportions of various forms of PSA in serum, particularly the proportion of free to total PSA, represents a new and exciting method of detecting early curable prostate cancers and avoiding unnecessary prostate biopsies in men who have BPH only.