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Abstract
The α thalassemias are common genetic disorders ranging from silent
to a very severe anemia due to reduced α globin chains. In our study a
screening of α thal deletions was made among 400 Egyptian neonates
using CBC, blood indices, alkaline pH Hb electrophoresis and single
tube multiplex PCR co-amplifying the 4 α globin genes simultaneously.
It was found that the number of α thalassemic neonates was 38 (9.5%
of all subjects). Deletions were divided as 4.5% α+ thal heterozygous (-
α/αα), 3% α+ thal homozygous (-α/-α), 1.75% α0 thal heterozygous (--
/αα) and 0.25% Hb H disease (--/-α) with no cases of α0 thal
homozygous (--/--). α+ thal was found to be the commonest allele.