الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The results of experiment I demonstrated that:
Pharmacologic interventions in the form of perioperative anticoagulation with LMW heparin, and non-absorbable antibiotics significantly improved survival rate, decreased hepatocyte injury and increased hepatocyte mitosis following PVL to 80% of the liver. The improvements in outcome acquired by additional splenectomy, however, were not significantly different from those of pharmacologic interventions alone. These interventions, however, are not sufficient to prolong survival enough for liver regeneration until its completion.
The aim of experiment II is to study the effect of simultaneous administration of adenoviral vector encoding HGF and VEGF genes 48 hours before PVL to 70% of dogs’ liver to enhance liver regeneration.
Experiment II divided into 3 groups (2dog/group): negative control group where saline were administered intravenously, positive control (LacZ) group where an adenoviral vector encoding a reporter gene (β-galactosidase) and a test group that received the recombinant adenovirus encoding HGF and VEGF genes. All groups were subjected to PVL to 70% of dogs’ liver 48 h after injection of saline and adenovirus.