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Abstract The present study was conducted on a flock of rabbits in Faculty of Veterinary Medicine, Alexandria University. The objective of the study was to evaluate the effects of crossbreeding on the performance of three breeds of rabbits (New Zealand White, Californian and Rex). The experiment was carried out on 47 rabbits of the three breeds and 259 of their purebred and crossbred progenies. The results obtained can be summarized as follows: * Crossbreeding (purebreds vs crossbreds) had a significant effect on litter size at birth. * Litter size at weaning was affected significantly by the breed, crossbreeding, year and season of birth and parity. * Litter size at birth and at weaning were highest for Rex breed (8.20 and 5.20, respectively), while the lowest value for litter size at birth was 5.50 for Rex x New Zealand White crossbrecls. Litter size at weaning was lowest in Rex x Californian crossbreds (3.85). * The breed of rabbits, female line, purebreds vs crossbreds, year and season of birth, parity, litter size at birth and litter size at weaning had significant effects on weaning weight of rabbits. * Weaning weight was highest in Californian x Rex crossbreds (458.64 gm) and lowest in Californian purebreds (313.27 gm). * The breed of rabbits and female line had significant effects on body weights at 45, 60 and 75 days of age. |