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العنوان
Studies on Pyridazines,Synthesis of New Compounds with Expected Biological Activity =
المؤلف
Mourad, Alaa El-Deen Mohamed Hamed.
هيئة الاعداد
باحث / علاء الدين محمد حامد مراد
مشرف / A. K Fateen
مشرف / Afaf A Nada
مشرف / A. M. A Emran
الموضوع
Pyridazines
تاريخ النشر
1977.
عدد الصفحات
p81. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/1/1977
مكان الإجازة
جامعة عين شمس - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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from 112

Abstract

3_Aryl-3-chlaropyricazines (53a-c) were prepared from the reaction cr c_dryi_2>3-c±Lhydrapyridazin-3-Qnes (52a-c) with phosphorus oxyChlo—
ride.
6-Aryl-2,3-ctLhydro-4-fnethyl-pyridazin-3-ones (56a-c) were prepared r’rom the reaction of 6—aryI.^-2.,3,4, 5-tetrahyDROPyridazin—3—ones (54a—c) *itn formaldehyde in alcoholic potassium hydroxide.
5-Aryl-3-chlara-4-rnethylpyridazines (57a—c) were similarly prepared by the action of phosphorus oxychloride on 6—aryl-2,3-dihydro-4-methyl-pyridazin-3—ones (56a-c), the infrared and ultraviolet spectra of the i-chloropyridazines obtained were discussed.
3-Chloropyridazines (53a & b) and (57a) reacted with sodium azide in n-butanol to give 6—aryl—tetrazolo ( 1, S-b ] pyridazines (60a & b) and c—(j,4—damethylphenylj-S-nnethyl-tetrazala [ 1, 5-b ]pyridazine (60c). The sane products (SOa-c) were prepared from the reaction of 3—chloropyrida— zines (53a & b) and (57a) with hydrazine hydrate, followed by nitrosa-tion of the unstable hydrazinopyridazines obtained (64a-c) to give the cyclic tetrazoles (60a-c).
When 6-aryl-3-chloropyridazines (53a & b) and 3—chlora—6-(3,4—di— methylphenyl)-4-methylpyridazines (57a) reacted with sodium methoxi.de, tney gave 3-fnethoxypyridazines (65a-c).