الفهرس 
Pathophysiology of delirium and POCDOnly 14 pages are availabe for public view
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Abstract
More than 50 years ago, clinicians reported changes in mental functions after anesthesia and surgery especially in the elderly, as these changes increase in prevalence in subsequent years they have categorized into distinct syndrome of postoperative delirium and postoperative cognitive dysfunction.
The pathophysiology of POD is still obscure but the most accepted hypothesis is disturbance in wide variety of central neurotransmitter system especially lack of acetyl choline and relative increase in dopaminergic transmission.
POD represents one of the threatening complications after major surgery; it’s defined as a a change in mental status characterized by impairment of cognitive functions, disturbance of attention and reduced clarity of awareness of the environment.