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Abstract
STUDIES ON THE NEUROPATHOLOGIC
ALTERATIONS IN RELATION TO THE EFFECT OF
SOME ANTIOXIDANTS IN ALBINO RATS
The present work was designed in order to evaluate pathologically the effect of feeding rats on diets mixed with low (5 %) or high (10 %) levels of two types of the plant origin antioxidants, olive oil and flaxseed oil. The evaluation was spotted on the study of the various histopathologic alterations that may be occurred in the nervous tissue of the brain and spinal cord.
In case of rats fed on diet with 5% olive oil, revealed presence of congestion allover the first 3 weeks of the experiment. At the end of the 4th week the congestion appeared to be associated with edema and some few extravasated erythrocytes. The rats fed on diet with 10% olive oil, showed some reactive as well as progressive changes were seen after 2 weeks of administration. At the end of the 3Id week vascular changes of congestion of the cortical and meningeal blood vessels of the cerebrum and cerebellum were detected and were associated with edema and focal gliosis. At the end of the 4 week the progressed lesions were manifested with some additional alterations of mononuclear cell infiltrations and aggregations as well as some mild changes of neuronal degeneration allover the various regions of brain tissue, especially cerebral peduncles, tectum opticum and medulla oblongata. No obvious changes could be detected in the spinal cord, except of those vacuolations at some of the peripheral areas, while the neurons were apparentlly normal
The histopathologic findings in case of fed on (5%) of the linseed oil, were somewhat more active than those in case of the olive oil. The congestion was seen early from the end of the 2nd week allover the deep and superficial blood vessels of the brain and spinal cord. These chanes were”accompanied with edema and hemorrhages during the following 3 and 4 weeks. The microscopic changes following administration with the high levels (10%) of linseed oil were manifested by the congestion sometimes hemorrhages at the choroid plexus and cerebral peduncles allover the first 2 weeks of the experiment. At the end of the 3Id week more severe lesions of congestion and hemorrhages were seen to be associated with several areas of focal gliosis and mononuclear cell aggregations, widely distributed allover the brain tissue. Some areas of vacuolation, neuronal degeneration and satellitosis were also seen, especially in the cerebral cortex, hypothalamus and tectum opticum. At the end of the 4th week more progressive changes (severe congestion and hemorrhages, edema, gliosis, mononuclear cell infiltration and aggregation as well as neuronal degeneration and necrosis with several areas of vacuolations due to demyelination) were seen to be involving’ the various regions of brain tissue and spinal cord.