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Abstract The aim of the work to study the effect of induced hypotension using SNP (as a hypotensive agent) on the heart, this was achieved by reporting changes in electrocardiograms, and myocardial enzymes (CPK & LDH), and their cardiac is enzyme and to determine whether such changes persisted into the postoperative period. In conclusion, induced hypotension by SNP and halothane under controlled respiration revealed ECG changes ranged in severity between the less dangerous and long standing subenocardial infarction. These ECG changes were proved by the rise of myocardial enzymes (CPK and LDH) and their cardiac isoenzymes especially the highly specific CK-MB. This study concluded that the rapid rates of fall of systolic blood pressure and prolongation of hypotensive periods were responsible for these ECG changes. In this work, the high incidence of ECG changes (47.8%) encourage us to advise anesthesiologists to use this technique within narrow limits and only when it is indicated especially in elderly patients suffering from one of the risk factors. When an anaesthesiologest has to use the technique of induced hypotension he must keep an open eye on the rate of fall of systolic blood pressure and the length of hypotensive period; monitor ECG changes especially during the hypotensive period and estimate at least the highly specific CK-MB isoenzyme. |