الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
The 2-furanone ring constitutes an integral part for many biologically active natural products. It has also been implicated in a variety of synthetic molecules which showed interesting pharmacological properties, the most important of which are anticancer, antimicrobial, anti-inflammatory and antioxidant activities.
On the other hand, the wide spread of cancer in the recent years encouraged many authors to search for new therapeutic agents in these areas with precise selectivity and less toxicity. The past two decades have witnessed a dramatic development in understanding the role of cyclin-dependant kinases (CDKs) in the control of cell cycle progression and the genetic basis of carcinogenesis and many other diseases. The contribution of cyclindependant kinases in the etiology of undesirable cellular proliferation related disorders such as cancer, growth of viruses, fungi, parasites and other conditions, reflects that cell cycle deregulation represents an essential step in the multistep process of pathogenesis of such disorders. Consequently, CDKs have been utilized as potential therapeutic targets of promise in diseases where control of inappropriate cellular proliferation would be of therapeutic benefit.
Based on these grounds and in continuing the search for new small molecules of potential activities in this area, the design and synthesis of some furan-2(511)-ones and derived quinoxalinones were proposed. The substitution pattern of the target furanones was inspired from two lead furan-2(511)-one derivatives and realized by the use of properly substituted 4-aryl-2-oxo-but-3-enoic acids (arylidenepyruvic acids), as intermediates, in the synthetic route.
In an attempt to explore the antioxidant property of the ring system, the oxidation of some furanones with hydrogen peroxide was also studied.
The thesis is subdivided into the following parts:
Introduction:
The introduction gives an insight on the cell cycle regulation and the expected biological role of chemical inhibitors of cyclin dependent kinases in the management of interfering diseases occurring due to undesirable cell proliferation. Moreover, some selected models of compounds possessing CDK inhibitory activity are included. Recent researches on biologically active 2-furanones as anticancer, antimicrobial, anti-inflammatory and antioxidant agents are also reviewed.
Research objectives:
It deals with the chemical and biological rationale upon which the synthesized compounds have been designed. It was planned to screen some selected compounds for anticancer, anti-HIV and antimicrobial activities.