الفهرس 
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Abstract
The aim of this study is to assess the condition of the liver in accidentally discovered anti-HCV positive individuals on clinical, laboratory, sonographic and histopathological bases. Follow up of these patients whom do not accepted to receive antiviral drugs and attempted to correlate these with the progress of disease and to detect the factors influences progression of the disease.
Conclusions
From This study it was concluded that the unapparent parenteral routes seems to have a role in the transmission of the virus more than blood transfusion.
In asymptomatic, accidentally discovered subjects with positive anti-HCV, PCR is almost positive even in the presence of normal ALT levels and there is usually an underling CAH.
PCR test and the histological evaluation continues to be the most accurate diagnostic predictors acquired for clinical assessment of patients with chronic hepatitis.
Patients with chronic hepatitis C who have show a more liver pathology than those with chronic hepatitis only.
Patients with age above 40, multiple risk factors of infection, serum HCV-RNA positivity, abnormal ALT level, abnormal prothrombin time & concentration and abnormal platelets count had more risk for progressive liver disease.
The age above 40 years, positive HCV-RNA, and presence of other factors of liver damage (Bilharziasis and/or positive HBV seromarkers) are considered as an independent predictors of progression in patients with chronic hepatitis.
Recommendations
More studies on larger scale for further identification of risk factors and the natural history of the disease.
Further studies to correlate the HCV genotype and the prognosis of the patient as regard severity of hepatic affection and its relations to the mode of infection and risk factors.
Other studies for possible preventive measures for hepatitis C.
PCR test for HCV-RNA in serum should be done as a follow-up test for progression of chronic hepatitis to other liver diseases.
Patients with positive HCV-RNA, other factors of liver damage (Bilharziasis and/or positive HBV seromarkers) and age above 40 years are need for rapid aggressive treatment of chronic hepatitis to avoid progression.