الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Variety of thiophene and thienopyrirnidine derivatives have been prepared along the past decades. Biological evaluation of these classes of compounds revealed that several derivatives were effective as antimicrobial, antimalarial, anthelmintic, antiviral, anticancer, antihypertensive, antihyperlipidemic, antipsychotic, antiulcer, antiallergic, analgesic and antiinflammatory agents. This led many research workers to embark on
extensive programs on the synthesis of new compounds incorporating thiophene and thienopyrimidine nuclei with the hope of developing agents
with stronger biological potentialities. As a result, large number of active thiophene and thienopyrimidine derivatives have been discovered and some proved to be efficient for application on the clinical levels.
Our interest in the chemistry and biological effects of sulfur-containing compounds motivated the synthesis of new thiophenes and thienopyrimidines bearing various functionalities which reserve antibacterial
activities to the products.
The synthetic procedures involved the application of the cyclodesulfurization reaction, which has been developed and established in our laboratories, as well as several other routes of wide application for the synthesis of the compounds in question.