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Abstract
a) The pathogenesis of peptic ulcer disease (PUD) is multifactorial including; Helicobacter pylori infection, gastric acidity, pepsin, gastrin, gastroduodenal motility, smoking of nicotine and a possible role of gastric vasopeptides.
H.pylori is considered as the major pathogen in the pathogenesis of PUD, but the mechanism of its action has not been fully explained.
Previous studies have shown that H.pylori infection leads to an increased production of reactive oxygen species within the gastric mucosa which are thought to play a major role in the mediation of associated disease. Recent studies have shown differences in the availability of an important antioxidant, glutathione, during chronic H.pylori infection.
The aim of this work was to study the interplay between Helicobacter pylori infection, Malondialdhyde as an end product of gastric mucosal lipid per-oxidation and reduced glutathione as a window to look through for the reactive oxygen species activity. Also, we aimed to study the serum levels of vitamin A, vitamin E and selenium and their possible protective role against gastro-duodenal H.pylori-associated diseases.
This study had been carried out in Hepato-Gastro-Enterology and Endoscopy Unit, Internal Medicine Department, in co-operation with Medical Biochemistry Department, Faculty of Medicine, Zagazig University during the period from December, 2004 to March, 2006.