الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The wide spread of cancer and acquired immune deficiency syndrome in recent years obligated the continuous search for new therapeutic agents in this field.
As a part of an ongoing program aimed towards the development of new potential antitumor and anti-HIV, the synthesis of diverse furanones and their derived pyrazoles and quinoxalines was projected.
The deregulation mechanisms of cyclin-dependant kinases (CDKs) in some human tumor progression prompted the testing of some selected compounds as CDKs inhibitors in addition to other screening protocols.
The present thesis is subdivided into the following parts:
Introduction
It comprises a review of the literature concerning the cell cycle regulation and the unique role of CDKs inhibitors in interfering undesirable cell proliferations, in addition to a presentation of selected models of compounds having CDK inhibition activity and I or antitumor effect. The importance of 2-furanones, pyrazoles and quinoxalines in this area, is also reviewed.
Research objectives
This part deals with the chemical and biological bases on which the synthesized compounds were selected. It was also planned to screen some selected compounds for their anticancer and anti-HIV activity.
Discussion
In this part, the various methods applied for the synthesis of the intermediate and final compounds are discussed. Reinvestigation of some of the adopted processes have been detailed. The structures assigned to the prepared compounds were substantiated by elemental analyses, IR, ‘HNMR, ‘3C-NMR and Mass Spectral data. The discussion is subdivided into 3 parts.