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العنوان
Clinico-Epidemiological & Treatment Evaluation of Adult Non-Hodgkin’s Lymphoma Patients in Minia Oncology Center /
المؤلف
Abdel-Megeid, Emad Ismail.
هيئة الاعداد
باحث / عماد اسماعيل عبد المجيد
مشرف / عماد محمود حمادة
مشرف / امانى صابر جرجس
مشرف / ميرفت محروس
الموضوع
Cancer - Statistics. Cancer - Reporting - Statistical methods.
تاريخ النشر
2007.
عدد الصفحات
136 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأورام
تاريخ الإجازة
1/1/2007
مكان الإجازة
جامعة المنيا - كلية الطب - الاورام
الفهرس
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Abstract

During the period from January 2001 to December 2005, the number of adult N.H.L cases (more than 19 years) presented during this period was560 cases representing 4.5 % of total malignancies.
Out of 560 patients, regarding the histo-pathological grades, 152 patients (27.1%) were of low grade, 396 patients (70.7%) were of intermediate grade and 12cases (2.1%) were of high grade lymphomas. Among 560 patients included in this study only 407 (72.7%) patients were eligible for treatment evaluation, while 153 patients (27.3%) were considered non- eligible in the present study. In order to consider the patient eligible for response assessment, he should have received at least three regular cycles of systemic chemotherapy in proper time. Out of the 407 patients with NHL (333) cases received chemotherapy alone, (65) cases received combined chemo-radiotherapy and only (9) cases received radiotherapy alone.
Assessment of treatment and statistical analysis of these (407) cases, 160 patients achieved CR, 150 achieved PR and 97 cases were primary refractory to treatment. Of the 160 cases who achieved CR to treatment, relapse occurred in 37 cases (23.1%) “Secondary failure”. Among the 37 relapsed cases, 23 cases received second line treatment, while 14 patients lost follow up. And the over all response after treatment was found to be: eight patients (8/23) succeed to achieve a second CR, (9/23) patients achieved PR while (6/23) patients was refractory to second line treatment. Eligible Patients in this study (407 cases) were followed up for a median period of 25months (7-60 months).actuarial 5-years overall survival for this group were (23.5%) and disease free survival for the 160 cases who achieved CR were (52.4%).