الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The present study attempted to evaluate the possible involvement of the male gonadal hormone, testosterone, in the elicitation of two important deleterious effects of CyA, baroreflex and renal dysfunctions. In-vivo and ex-vivo studies were performed to assess baroreflex and renal vascular responsiveness, respectively,
in SO, CAS, and CAS+T rats in the absence and presence of CyA. For measurement of baroreceptor function, baroreflex curves relating peripherally-mediated increments and decrements in BP to
the associated reciprocal changes in HR were constructed in conscious freely moving rats. The slopes of the curves were taken
as a measure of baroreflex sensitivity. The roles of vagal and sympathetic autonomic components in CyA-testosterone baroreflex interaction were also investigated. The renal vascular reactivity was evaluated by measuring changes in renal perfusion pressure of the isolated kidney in response to a1-adrenoceptor activation by PE and endothelium-dependent and independent vasorelaxants (ACh and NP, respectively). The slopes of the dose-response curves, ED50, and Emax of the three vasoactive agents were compared to determine the individual and combined effect of CyA and testosterone on renovascular reactivity.