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Abstract
The effect of Nigella sativa on male rats administered diazinon was studied in four groups ( control, diazinon, Nigella sativa plus diazinon, Nigella sativa). Diazinon decreased serum SOD activity and increased MDA production in liver and kidney and also erythrocyte Catalase activity, however GSH content not affected. Hepatotoxicity and nephrotoxicity of diazinon were evidenced by histopathological findings. Diazinon also severely decreased Acetyl cholinesterase activity, weight of rats and globulins and total proteins while albumin not affected, the immunotoxic effect of diazinon supported by histopathological exam of spleen. In the group which treated with Nigella sativa and diazinon together, Nigella sativa normalized the toxic effect of diazinon completely except Acetyl cholinesterase which was improved but not reach to normal value. On the other hand, Nigella sativa treated group showed an increase in serum SOD activity, erythrocyte Catalase activity and renal GSH however hepatic GSH decreased and also MDA level decreased in liver only and increased in kidney. Moreover Nigella sativa greatly elevated Acetyl cholinesterase activity and weight of rats. Histopathological findings of liver, kidney and spleen show normal picture. So the result conclude that Nigella sativa protected rats from diazinon toxicity.