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العنوان
Potential Interactions Between Gilimepride and Candesartan in Alloxan-Induced Diabetic Rats.
الناشر
Walaa Yehia Abd-El Zahr,
المؤلف
Abd-El Zahr, Walaa Yehia
هيئة الاعداد
باحث / Walaa Yehia Abd-El Zahr
مشرف / Hussien Ismail Ahmed El-Bitar
مشرف / Osama Mohammed Ashour
مشرف / Salwa Abd El-Twab Ibrahim
الموضوع
Gilimepride Pharmacology Candesartan Pharmacology Alloxan-Induced Diabetic Rats Pharmacology
تاريخ النشر
2008 .
عدد الصفحات
229p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب (متفرقات)
تاريخ الإجازة
19/1/2009
مكان الإجازة
جامعة المنيا - كلية الطب - Pharmacology
الفهرس
Only 14 pages are availabe for public view

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Abstract

The effects of chronic administration (6 weeks) of the two drugs under investigation either separately or in combination on the blood glucose level (BGL), liver glycogen contents, serum lipids profile (cholesterol, triglycerides and HDL) as well as histopathological studies were evaluated. Besides, second set of experiments were designed to investigate their effects on the oxidative stress parameters (malondialdehyde (MDA) and glutathione peroxidase (GPx) activity), serum nitric oxide (NO) level and C-reactive protein (CRP) titer.
Results revealed that alloxan-induced diabetes in rats caused significant increase in BGL and reduced the liver glycogen contents. It also caused significant increase in the levels of total serum cholesterol and triglycerides accompanied by decrease in HDL.