الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Aim of the work
To compare diazepam and midazolam as an I.V. sedatives during spinal analgesia regarding their sedation level according to sedation score, and their effects on blood pressure, pulse rate, respiratory rate and blood gases.
Summary and conclusions
As regards, the respiratory system, it was found that both drugs produced transient hypoventilation which expressed as reduction in minute volume and increase in respiratory rate and reached to the normal level about 60min. after injection of sedatives. As regard the effect on blood gases, there was insignificant effect on pH or PCO2 but there was a highly significant decrease in PO2 and SaO2% (P<0/01 respectively) during maximal sedation signify the need for routine O2 administration in patients undergoing spinal analgesia with concurrent sedation unless a pulse oximeter is available for monitoring SaO2%.
In conclusion: midazolam could be a better alternative to diazepam as sedative drug during spinal analgesia and spinal analgesia should not be combined with I.V. sedation with either diazepam or midazolam unless there is routine administration of oxygen or pulse-oximeter is available to monitor SaO2%.