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Abstract Aim of the work To compare the effect of magnesium sulphate and lidocaine on the stress response of laryngoscopy and endotracheal intubation in controlled hypertensive patients. Conclusion and recommendations Magnesium sulphate is superior to lidocaine an attenuating the stress response to endotracheal intubation. Magnesium sulphate when given before induction in a dose (50mg/kg) I.V. is better than lidocaine when given in a dose (1.5mg/kg) I.V., in attenuating the rise of H.R, SBP, DBP, MAP, with more favorable intubation condition, especially in controlled hypertensive patients, who are liable to exaggerated response, but given with caution in patient treated with Ca channel blockers as incidence of hypotension increases due to the same mechanism of action. We recommend studying the effect of magnesium sulphate in attenuating the pressor response to endotracheal intubation in controlled hypertensive patients undergoing emergency surgery in another study. |