الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
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Abstract
Since 8—hydroxyquinoline was synthesized and introduced into clinical therapy as an effecient broad— spectrum antimicrobial agent, several efforts have been reported on the synthesis as well as biological screening of other related compounds especially halogenated quinolines which proved to increase the antifungal as well as antimicrobial activities. Of these efforts much interest was devoted to the investigation of such a variety of haloge— nated quinolines, of which 5—chloro—8—hydroxy—7—iodoquinoline has long been used topically and before the advent of polyene antibiotics, was employed orally for intestinal candidiasis.
Moreover, it was discovered that(thiocarbamoyl)hydrazones of some aromatic aJ.dehydes possess antiviral activity. A common structural feature that can be easily recognized in these compounds is the incorporation of’ the (—N—NH—cs—NH) group. For this reason, the preparation of a series of (thiocarbamoyl) hydrazone derivatives supported on 2—chioro— quino].ine moiety was achieved, namely:
1. 2—chloroquinoline—3—carbaldehyde thiocarbamoylhydrazone.
2. 2—chloroquinoline—3—carbaldehyde p—tolyl(thiocarbamoyl)— hydrazone.
3. 2—chloroquinoline—3—carbaldehyde o—tolyl(thiocarbamoyl) hydrazone.