الفهرس | Only 14 pages are availabe for public view |
Abstract Pseudomonas Aeruginosa is an opportunistic pathogen, responsible for frequent nosocomial and burn infections. It is also the major pathogen in chronic pulmonary infection of patients with cystic fibrosis (CF). The isolates that initially infect the lungs of CF patients have a non-mucoid phenotype typical of those isolated from other environments such as soils and waters. These initially infecting strains are highly motile and secrete high levels of destructive proteins. After this initial infection, P. aeruginosa undergoes a number of important morphological changes that give rise to mucoidy. These mucoid phenotypes in CF patients are generally non-motile and express lower levels of destructive proteins. |