الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Infection represents a major problem in
patients wit)!.renal failure and uraemia. In attempting
to define factors which may provide the basis
for this clinical observations there appear to be
mUltiple potential determinations. Among these could
be included increased exposure to potential hazard
of exogenous microbial agents in the hospital environment
as well as defective host defense mechanisms.
The later would include these immune mechanisms mediated
through B-cell lines by the production of
specific immunoglobUlins and those mediated through
T-Iymphocytes and definided as cellular immunity.
The aim of this work to study the behaviour
of the immune system in patients with chronic renal
failure on haemodialysis and peritoneal dialysis
for varying periods and to form an immunological
profile for a patient with chronic renal failure bn
t’\~
dialysis standing for renal transformation.
Our study was carried out on 30 patients
treated by haemodialysis or peritoneal dialysis for
one month, 3 months and one year :
Group 1 : Fifteen Chronic Renal Failure Patients .
treated with intermittent haemodialysis
of average age 39 years and average serumcreatinine
before dialysis 13.5 gm.%.
Group 2 : Fifteen chronic Renal Failure Patients
on intermittent peritoneal dialysis with
average age 40 years and average s~rum
creatinine 15.3 mg.%.
In addition to ten control cases also ineluded.
The following tests were done for those
patients :
A. ~.l:~2!..~~~-!!!!JII.tJX’!ni
1. Delayed hypersensitivity skin tests:
a. Purified protein derivatives (Tuberculin
test) •
.b. Dintro chlorobenzene (D.N.C.B.).
2. E. Rosette.
3. Active E. Rosette.
B. ~.!:s for Humoral I!!!M~ni.!l
1. Quanti tation of B lymphocytes. by immunofluorescent
method.
2. Quantitation of immunoglobulin level (IgG,
IgA and IgM) by radial immuno-diffusion method.
The results showed:
1. There was decreased number and function of
T lymphocytes in uraemic patients comparable
to normal controls in E. Rosette and active
E. Rosette and skin tests. The number and function
of T lymphocytes were not improved after
haemodialysis at any time of the study. On the
other hand it had been found that the number
and functions of T lymphocytes were improved
in E. Rosette, active E. Rosette and skin tests
after peritoneal dialysis. There was no improvement
in parameters of humoral immunity either after
haemodialysisnor peritoneal dialysis.
w~concluded that there was marked depression
of cellular immunity in chronic renal failure
patients wich is not affected by haemodialysis
but improved after three months and one year of
peritoneal dialysis. Humoral immunity in chronic
renal failure patients were normal and not affected
either by haemodialys nor by peritoneal dialy’sis~
So uraemic patients prepared for kidney
transplantation must treated by haemodialysis because
it does not affect cellular immunity.