الفهرس Only 14 pages are availabe for public view
 |  | from | 143 |  |  |
| | | from | 143 | | |
Abstract
Hypoalbuminemia (serum albumin < 33 gmIL) is cornmon finding in
critically ill children. Serum albumin level have significant influence on
acid-base interpretation in critical illness through calculation ofanion gap
which is affected by negativecharge on albumin.
Several recent studies in critical ill patients have demonstrated the
effect of hypoalbuminemia in interpretation ofacid-base disturbances and
its effect on anion gap.
In our study, we aimed to detect, characterize and quantify complex
metabolic acid-base abnormalities using pathophysiologic evaluation of
acid-base balance which takes in account change in independent
variables, PC02, SID and concentration of non-volatile weak acids
(mainly albumin) and dependent variables; pH, BE and [HC03”].
This study was carried out at Pediatric Intensive Care Unit (PICU),
Zagazig University Hospitals in the period from October 2004 to October
2005. Our study included 150 critically ill patients whom were admitted
in PICU and had disturbances in acid-base status anellor disturbances in
serum albumin level, ~ 93 were males (62%) and 57 cases female
(38%) and 10 subjects ascontroI.
All the study population was subjected to the following:
1- History taking.
2- Clinical examination.
3- Laboratory investigations including:
• Arterial blood gases.
• Serum electrolytes.
• Serum albumin level.
In this study, we found that with traditional approaches for detection
of acid-base disturbances, about one-fifth of cases has [HeO)’] and base
excess within normal level but with pathophysiologic evaluation, we
found that these cases had grave metabolic acid-base disturbances and all
of them had hypoalbuminemia.