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Abstract me microencapsulation and floccu1tion techniques as method for prolonging the release rate of drugs has rwn the attention of pharmaceutical scientists. Accordingly they are finding increased use in pharmacyfrom the technological as well as from the clinical and therapeutic aspects. Natural and synthetic polymers, waxes and ninny other materials, either alone or combined have been employed as coating materials in drug microencarsulation. There is however little information of work done on microencapsulation of pharmaceuticals specially with cellulose polymers as the encapsulating material. In this respect, this current investigation was motivated and designed to provide information about the peten— tial of some synthetic cellulose polymers and sodium alginate to delay the release of drugs from oral pharmaceuticals. Coating of drugs was carried out applying two relatively recent techniques namely; microencapsulation and flocculation. The polymers used in this study were: Dthy1co1lu1ose, Meth.jrlce1luloe, Cellulose triacetate, Cctrboxjnnethylcellulose and Sodiurn alginate. Chloramphenicol and sulphadiazine were used as model drugs. The experimental work carried out in this study comprised the preparation of four microcapsules and three floccu— les. Three of the microencapsulation methodo1or adopted |