الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The strategy of designing NSAIDs capable of generating the radical biomediator and gastroprotective agent NO became one of the most important techniques used by the pharmaceutical industry to develop effective anti-inflammatory agents with enhanced safety profile. This is attributed to the fact that NO upon its release has the ability to increase the mucosal blood flow resulting in enhanced mucosal resistance to ulceration. In this thesis we tried to use the same technique through preparation of some novel pyrazoline derivatives with expected anti-inflammatory and antibacterial activies, in addition; a group of NO-donating pyrazoline derivatives were prepared in order to study the effect of the incorporation of the NO-donating groups on both the biological activities and side effects of the parrent pyrazoline derivatives.