الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
In the present study, an attempt has been made to evaluate the antiulcer activity of the novel histamine H2-receptor antagonist, pibutidine hydrochloride (IT-566), in cold-restraint stress and ethanol-induced ulcers. Also, the possible involvement of NO and PGs in the pibutidine-protective action was investigated. The results obtained in the present study clearly demonstrated that: -Ulcerative lesions were observed in CRS and ethanol-treated rats where the ulcer indices were 17.3 and 21. respectively. -Administration of pibutidine to CRS and ethanol-treated protected from gastric ulceration and reduced the ulcer indices to 5 and 10.5, respectively mounting the preventive indices to 71 and 50, respectively. -Coadministration of L-NAME with pibutidine abolished the increase in the volume, free and total acid output, pepsin output and mucin cincentration of thegastric secretion induced by administration of pibutidine alone to CRs rats. Inconclusion, pibutidine protected gastric mucosa from cold-restraint stress and ethanol-induced gastric lesions. The protection afforded by pibutidine was superior to that afforded by famotidine. The proposed mechanisms of pibutidine`s gastroprotection may include;Firstly its H2-receptor antagonistic action through inhibition of the gastric juice acidity and pepsin concentration, Secondly, pibutidine`s ability to stimulate or induce NOS activity in rat gastric mucosa which increases NO production that mediates the protective action of pibutidine by a direct increase in mucosal blood flow, stimulation of gastric mucin release, scavenging of free radicals and induction of PGE2 synthesis, and thirdly, the least important character of pibutidine, the direct antioxidative ( free radicals scavenging) activity.