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Abstract
Monoclonal antibodies are remarkably versatile agents with potential therapeutic applications in a number of human diseases, including cancer. They have great potential to be safe and effective anticancer agents, either alone or in combination with other more conventional agents. Antibodies are produced in the lab by fusing a myeloma cell from a mouse with a mouse B-cell that makes a specific antibody called a hybridoma, which was first discovered by Kohler and Milstein in 1975. Allowing the hybridoma to multiply in culture, it is possible to produce identical antibody molecules, these antibodies are called monoclonal antibodies, because they are produced by identical offspring of a single, cloned antibody-producing cell.