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Abstract
Disturbance of esophageal motility and gastroesophageal reflux
diseases are commonly encountered in cirrhotic patients and have been
suggested to be responsible for upper digestive symptoms and a pathological
gastric acid reflux. Gastroesophageal reflux disease and esophageal
dysmotility in cirrhotic cases have been shown to be influenced for great
instance by the level of gastrointestinal hormones in the senun and its
disturbance may lead to the appearance of digestive complaints in cirrhotic
patients.
So, this work evaluated the plasma concentrations of gastrin and
somatostatin hormones in compensated liver cirrhotic patients aiming at
finding any relation of both hormones and their impact on the occurrence of
esophageal motility disorders, and gastroesophageal reflux in such patients
This work had been conducted in Tropical Medicine Department and
Biochemistry Department, Zagazig University Hospital, and performed on
two groups:
”, First group (patients’ group): 40 patients with compensated liver
cirrhosis associated with dyspepsia after exclusion of other diseases that
affects gastrointestinal motility
Second group (control group): 20 individuals with dyspepsia and not
suffer from other diseases.
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Both groupswere subjected to:
~ Full history taking,
~ thorough clinical examination (exclude pregnancy, ascites)
- Laboratory investigation, such as liver and kidney function tests to
exclude advanced diseases and diseases that affect esophageal motility
such as diabetes mellitus, thyrotoxicosis, gall bladder diseases,
- Electrocardiography (ECG) to exclude cardiac disease as a cause of
chest pain.
~ Abdominal ultrasonography and upper GIT endoscopy.
,
~ Liver biopsy to confirm diagnosis of cirrhosis.
- Esophageal motility study and ambulatory 24 hours pll monitoring.
- Serum gastrin and somatostatin concentrations were determined
radioimmunologically after overnight fast.