الفهرس 
Introduction and Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
In the present study an attempt was undertaken to investigate any possible antiatherogenic properties of some calcium channel blockers against atherosclerosis induced by 1% cholestrol feeding.
The drugs selected for this investigation include diltiazem and nicardipine.
In the present study, male new zealand white rabbits were subjected to an atherogenic diet and were classified into for main groups; normal control control atherosclerotic,
- treated atherosclerotic; and nicardepine-treated atherosclerotic groups.
Diltiazem was administrated intraperitoneally and nicardipin was administrated intramuscularly for 2 months.
The results obtained in the present study clearly demonestrated that:
Oral administration of cholesterol 1% produced significant increase of the body weight of the rabbits in each group after 4 and 8 weeks. Also oral administration of diltiazem and nicardipin produced non-significant change in the body weight.
from the present work , it can be deduced that atherosclerosis in rabbits is accompanied by an increase oxygen free radicals formation that account for the increased lipid peroxidation, as well as a marked decrease of the antioxidant defense mechanism represented by the decrease in the activity of the anti oxidant enzymes. This can contribute to the pathogenesis of atherosclerosis.
We conclude that nicardepine and dilitazem have protective effects from lipid peroxidation, which may be mediated via tissue glutathione peroxidase enzyme.