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Abstract
(45) COPD patients and (10) age matched controls were studied
for determination of the type of disturbances of (RAAS) in patients
with COPD and the following results were obtained:
Both (PRA) and (PA) were significantly higher In patients with
COPD than that of controls and correlated positively with each
other.
There was no effect of sex, body weight, or age on (RAAS).
Weak effect of smoking on (RAAS) stimulation was noticed and the
pack year of smoking correlated positively with the degree of
(RAAS) stimulation.
Edema in COPD patients was associated with higher levels of
CRAAS) stimulation.
Hypercapnic patients showed higher values for both (PRA) and CPA)
than normocapnic.
Hypoxemic (COPD) patients showed higher values for both (PRA)
and CPA) than non hypoxemic ..
(PRA) values were higher in severe than in moderate COPD and the
least values were in mild subgroup.
(PA) was higher in moderate than in severe COPD and the least
values were in mild subgroup.
The need for mechanical ventilatory support was associated with
higher values for (RAAS) stimulation.
Mechanical ventilation caused further initial rise for (PRA) and (PA)
values that returned back to less than the original preventilatory
values after successful weaning.