الفهرس Only 14 pages are availabe for public view
 |  | from | 146 |  |  |
| | | from | 146 | | |
Abstract
Hepatocellular carcinoma (HCC) represents the fifth most frequent malignancy in the world and the third cause of cancer related death. Early diagnosis of HCC and accurate monitoring for post-operative recurrences are still the keys for improving the effectiveness of surgical treatment Adhesion molecules (AdMs) are glycoproteins expressed on all cell surfaces. They play a decisive mechanical role in the binding of a cell to another cell, either to the extracellular matrix (ECM) or to its environment The soluble intercellular adhesion molecule-1 (sICAM-1) is a member of the immunoglobulin gene superfamily of adhesion molecules and has a relative molecular weight of 90 K.D It is expressed by several cell types, including leukocytes endothelial cells, hepatocytes and activated T lymphocytes. It acts as ligand for B2-integrin molecules such as leukocyte-function-associated antigen 1(LFA-I) and mediates leukocyte trafficking to the site of inflammation so it is considered as an important early marker of response to inflammatory mediators and immune activation An increased level of sICAM-1 was found in many acute and chronic inflammatory disorders and also elevated in different malignancies. SICAM-1 may acts as mediators in the metastatic process Recently, it is proved that hepatitis C virus infection and development of HCC on top greatly affect the serum profile of sICAM-1There have been recent reports which described a relationship between sICAM-1 and hepatocarcinogenesis and that sICAM-1 is produced and secreted by tumor cells and may be used as a marker for progressive liver disease and therefore could improve detection and management of HCC Since the patients with hepatitis C virus (HCV) can fulfill the