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Abstract
Parkinson’s disease is the most common serious movement disorder in the world, affecting about 1% of adults older than 60 years.Patients with PD have a wide range of neuropsychiatric symptoms including several psychiatric manifestations as well as sleep disturbances.The aim of the current study was to explore the profile of neuropsychiatric and sleep disorders in patients with PD, to examine the relations between these disorders and the demographic and clinical variables.The subjects of this study included the following groups:(1) Patient group: includes thirty patients with PD diagnosed according to United Kingdom PD Society Brain Bank Clinical Diagnostic Criteria (UKPDSBB).This group was subdivided into:Subgroup (A) ( 20 patients): - receiving levodopa treatment.Subgroup (B) ( 10 patients): - not receiving levodopa treatment for at least one month before examination.(2) Control group: included twenty subjects matching with the patients regarding age and sex.The patients and control groups were subjected to:2. Thorough clinical assessment including history taking and examination including routine laboratory investigations.3. Semi-structured clinical interview for DSM IV (SCID).4. Mini Mental State Examination (MMSE).5. Sleep questionnaire 6. Neuro radiological tests: Computerized tomography (C.T.) and/or Magnetic Resonance Imaging (M.R.I.) of the brain to exclude other causes of parkinsonism.