الفهرس 
Respiratory Distress Syndrome
Prevention and treatment of RDSOnly 14 pages are availabe for public view
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Abstract
Respiratory distress syndrome is one of the most common lung disorders in preterm infants, where RDS represents the single most important cause of mortality and morbidity. RDS in preterm infants had been associated with inflammatory processes in the lung.
The present study aimed to evaluate sICAM-1 at birth in preterm newborns with RDS as a marker of inflammation in pathogenesis of RDS, and its progression to BPD.
This study was conducted on 20 preterm newborns with RDS (13 males and 7 females) and 20 healthy preterm control newborns (8 males and 12 females), who were recruited from the neonatal intensive care unit of Obstetrics and Gynecology Hospital, Ain Shams University over a period of 6 months.
Those who had suspected or proved neonatal sepsis, perinatal asphyxia and congenital anomalies were excluded from the study.
Umbilical cord blood samples were collected immediately after birth to asses sICAM-1 level and estimated as a marker of inflammation. Statistical analysis of the data were done.
The results of the present study revealed the following: (1) Males and females show no significant difference as regard demographic data. Healthy neonates and RDS neonates didn’t show any difference in GA or BW; but they show a highly significant difference in the mode of delivery, as RDS was common in CS.
(2) Level of sICAM-1 was significantly elevated in RDS neonates compared to healthy preterm neonates.
(3) Positive correlation between cord sICAM-1 and gestational age and birth weight in RDS neonates. No correlation was detected between cord sICAM-1 level and mode of delivery or Apgar score at (1), (5) minutes.
(4) Positive correlation between cord sICAM-1 level and days needed on IPPV or O2 therapy. Also, there was a positive correlation between different grades of RDS and sICAM-1 level representing a correlation to severity.
(5) Positive correlation between cord sICAM-1 level and development of BPD in RDS neonates.