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Abstract
Nuclear pharmacy is a special area of pharmacy practice that deals with
compounding and dispensing of radioactive material which is called radiopharmaceutical for use in nuclear medicine procedures. These radiopharmaceutical is formed by
labeling of compound that known to be localized in specific area or receptor in human body using suitable radionuclide. By a specific detection device,it is possible to detect
the emission given off by this radioactive material and create images of the relative distribution of radioactive source in the body.
The growth of nuclear medicine has been due mainly to the availability of
radiopharmaceuticals; this single isotope is used in over 80% of all diagnostic procedures. Each year, roughly 25 million procedures are carried out with radiopharmaceuticals, and this figure is projected to grow at a rate of about 15% per annum. The availability of short lived generator, as the daughter product of long lived
Tc ( half-life: 6 hrs ) from the
Mo ( half-life: 67 hrs ) , is a major factor behind the universal use of this radioisotope. The parent radionuclide,
in abundant quantities by the fission of Uranium in a nuclear reactor, with a fission yield of 6%. There are several major producers that collectively have the capacity to produce enough Mo to meet current global demand. It is also possible to enhance the capacity of
Mo production to meet the expected increased demand.Technetium-99m
radiopharmaceuticals are used in several diagnostic procedures, from the use of pertechnetate for thyroid uptake to the use of Mo, is prepared
Tc-octreotide derivatives for imaging
neuroendocrine tumours. Owing to its multiple oxidation states,