الفهرس Only 14 pages are availabe for public view
 |  | from | 82 |  |  |
| | | from | 82 | | |
Abstract
Resistin is abundant in adipose tissue as it is constitutively produced there but they are present in very small amounts in the systemic circulation. Resistin level is regulated by a variety of factors, particularly food intake and the neuroendocrine system Resistin can modulate several molecular pathways involved in metabolic inflammatory and autoimmune diseases .In addition; there are possible roles for resistin, in obesity-related subclinical inflammation, atherosclerosis and cardiovascular disease The studied individuals were divided into 3 groups Group I: It consisted of 20 type 2 diabetic patients with coronary artery disease They were subclassified into two subgroups Subgroup A: It consisted of 12 diabetic cardiac patients underwent coronary catheterization. They were eight males and four females, with ages ranged between 40-64 years.Subgroup B: It consisted of eight diabetic cardiac patients diagnosed as acute myocardial infarction. They were five males and three females, with ages ranged between 38-60 years Group II: It consisted of 20 type 2 diabetic patients without coronary artery disease. They were 14 males and 6 females with ages ranged between 34-57 years these patients had no history of angina, other heart diseases, abnormal resting ECG findings, or positive results for an exercise stress test Group III: The control group, it consisted of 12 apparently healthy subjects as a control group. They were six males and six females with ages ranged between 32 54 years All individuals were subjected to full history taking, full clinical examination, body mass index, laboratory investigations in the form of fasting , 2 hours postprandial blood glucose level, glycated Hb (Hb A1c) , and lipids profile Serum hs-CRP was measured by turbidimetric method, while resistin assay was done by ELISA Statistical comparison was done between the different studied patients groups and the control group The results of the current study showed that There was no significant difference between the three studied groups as regards the age and gender Cholesterol, triglycerides, and LDL-C were statistically significant higher in diabetics than the control group (P <0.001), while HDL-C was statistically significant lower in diabetics than control group Cholesterol, triglycerides, and LDL-C were statistically significant higher in diabetic patients without CAD than in the control group, while HDL-C was statistically significant lower in the diabetic patients without CAD than in the control group Cholesterol , triglycerides, and LDL-C were statistically significant higher in the diabetic patients with CAD than in the control group, while HDL-C was statistically significant lower in the diabetic patients with CAD than in the control group There was no significant difference between diabetic patients with CAD and diabetic patients without CAD, as regards cholesterol, triglycerides LDL-C, and HDL-C There was no significant difference between the diabetic patients with CAD who underwent coronary catheterization) and the diabetic patients with CAD who were diagnosed as acute myocardial infarction, as regards cholesterol, triglycerides, LDL-C, and HDL-C The diabetics had higher mean hs-CRP than the control group, and this difference was highly significant, also the diabetics had higher mean resistin than the control group, and this difference was highly significant The diabetic patients with CAD had higher mean hs-CRP than the control group, and this difference was highly significant, also the diabetic patients with CAD had higher mean resistin than the control group, and this difference was highly significant The diabetic patients without CAD had higher mean hs-CRP than control group, and this difference was highly significant (P <0.001), also the diabetic patients without CAD had higher mean resistin than the control group, and this difference was highly significant (P <0.001). The diabetic patients with CAD had higher serum hs-CRP than diabetic patients without CAD, and this difference was highly significant (P 0.001 also the diabetic patients with CAD had higher serum resistin diabetic patients without CAD , and this difference was highly significant The diabetic patients with CAD who were diagnosed as acute myocardial infarction had higher mean hs-CRP than diabetic patients with CAD who underwent coronary catheterization, and this difference was highly< significant. In addition, diabetic patients with CAD who were diagnosed as acute myocardial infarction had higher mean resistin than diabetic patients with CAD, who underwent coronary catheterization, and this difference was highly significant.