الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Diabetes mellitus is a common metabolic syndrome results from
either insulin defienciency, insulin resistance or both and exerts
its systemic effects through hyperglycemia.
Both diabetic nephropathy and retinopathy are common
microvascular complications of diabetes and affects the quality of
life. DN results in end-stage kidney disease and DR affects vision
or even complete blindness.
Many previous studies world-wide searched for the association
between the ACE gene polymorphism and DN and/or DR.
Newest studies are searching for the association between the
ACE gene polymorphism and the incidence of diabetes per se.
Our study aims at searching for the association between the ACE
gene polymorphism and DN vs. DR. Our study includes 30
Egyptian type-II diabetic patients that are categorized into 3
different groups as follows:
- Group 1: includes 10 patients with isolated diabetic
retinopathy without nephropathy.
- Group 2: includes 10 patients without nephropathy or
retinopathy.
- Group 3: includes 10 patients with diabetic nephropathy
with or without retinopathy.
5 ml. of peripheral blood sample withdrawn from every patient to
search for the ACE gene polymorphism by using PCR. The
following data are obtained:
DD genotype is present in 70% of group 3 i.e. there is a 70%
possibility of Egyptian type-II diabetic patients will develop
diabetic nephropathy during their future life.
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So, early detection of ACE gene polymorphism can predict early
the development and progression of diabetic nephropathy. Thus,
early use of ACE-Is may delay the progression of diabetic
nephropathy.A