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Abstract
Chronic inhibition of nitric oxide synthase enzyme is one of the causesof hypertension and refers to the elevation in blood pressure associated with a decrease in vasorelaxant property of nitric oxide. Inhibition of NOS causes a marked decrease in the synthesis of NO in all blood vessels including renal arteries and resulted in vasoconstriction.the vasoconstriction in renal arteries in decreased renal blood flow which in turn stimlates the intrarenal baroreceptors to release renin form the renal in turn stimulates intrarenal baroreceptoes to release reninform the renal juxtaglomerular apparatus. elevated renin levels then, catalyze the hydrolysis of circulation angitensinogen to Ang-I and as a result of thecatabolism of Ang-I by angiotensin converting enzyme(ACE(