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Abstract
The current study describes the synthesis of Erythropoietin-which is a prohibited hormone by WADA-mimetic peptides [(AFIII54(chain I), (Ser)12AFIII54(chain II), AFIII54 with addition of Gly and Tyr in position 4 and 5 respectively(chain VI) ,AFIII54 devoid (Thr)9 and)Trp)10(chain VII) , (EMP3(chain III),(Ser)15EMP3(chain IV) ,(Ala)15EMP3(chain V), EMP3 with addition of Gly and Tyr in position 7 and 8respectively (chain VIII) and EMP3 devoid (Thr)12and(Trp)13(chain IX) ] by SPPS using microwave energy which accelerated reaction rate and improved the purities and yield.
Conformational analysis using FT-IR spectroscopy showed that most the synthesised peptides existed in α-helix structure