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Abstract Drugs physical properties are significantly important parameters in such a way that target the infected cells. Polymorphism has become a very significant branch of study either for academic research and pharmaceutical industries. According to the crystal structure the drug has different bioavailability and therapeutic response with bacteria. In addition, the electrostatic energies stored in the drug play an important role in the attraction or repulsion force against the DNA molecule. Such electrostatic energy is directly correlated to the dielectric constant. |