الفهرس 
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Abstract
A series of N-alkylphthalazinone was synthesized by the reaction of phthalazin-1(2H)-one derivatives (1a-c) with alkylating agents namely, propargyl, allyl bromide, epichlorohydrin, 1, 3-dichloro-2-propanol, 4-bromobutylacetate, and 1-(bromomethoxy)ethyl acetate to give the corresponding N-alkylphthalazinone 2a-c, 3a-c, 5a-c and 6a-c, acyclonucleoside derivatives 7a-c and 9a-c. Conversion of phthalazinone to phthalazin-1(2H)-thione and formation of a series from S-alkylphthalazine 12-14 and S-glucoside and riboside 15 and 17 under conventional and irradiation MW methods, deprotection of acyclo- and cyclonucleosides 7a-c, 9a-c, 15 and 17 in presence of MeOH/TEA and few DROPs of water give the corresponding free nucleoside 8a-c, 10a-c, 16 and 18. The structure of newly synthseized compounds assigned by using IR, 1H, 13C NMR and elemental analysis.