الفهرس 
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Abstract
This study was carried out in the Clinical Pathology and Internal Medicine Departments, Faculty of Medicine, Zagazig University Hospitals.
The study included 57 subjects classified into 3 groups.
Group I: It included 13 apparently healthy subjects.
Group II: It included 22 insulin-dependent diabetic patients. They were sub-classified into 15 NON LEAD and 7 LEAD.
Group III: It included 22 non insulin- dependent diabetic patients. They were sub-classified into 15 NON LEAD and 7 LEAD.
All patients and control subjects were subjected to the followings:
1- Full history taking.
2-Complete clinical examination.
3-Complete blood picture (CBC).
4-Prothrombin time (PT) and Partial thromboplatin (PTT).
5-C reactive protein (CRP).
6-Liver and kidney functions tests fasting and two hours post prandial serum glucose.
7-Lipid profile (total cholesterol, triglycerides, HDL- cholesterol).
8- Specific laboratory investigations:
• Glycosylated haemoglobin(HbA1c).
• Assay of fibrinogen.
• Assay of tissue plaminogen activator (t-PA).
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