الفهرس 
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Abstract
The pharmacokinetics of oxytetracycline (30 mglkg b.wt.) in the serum, milk
and urine were studied after a single intravenous and intramuscular injection in lactating goats. Pre-treatment with antiblood parasites drug (diminazene aceturate) on the kinetic parameters of oxytetracycline were also investigated. Microbiological technique was used for assaying the tested antibiotic. It was found that the blood concentrations revealed a biexponential decline that can be considered as two- compartment model pattern. The results showed that the pre-treatment with Idiminazene aceturate increases the serum concentrations of oxytetracycline at
different time intervals. It was concluded that diminazene aceturate alter the kinetic parameters of oxytetracycline. The drug showed very high bioavailability (97.54 ±
W.07 and 99.01 ± 16.54 %) in non-treated and diminazene pre-treated goats
respectively. The values recorded for creatinine clearance in pre-treated group were
;ignificantly higher than those recorded in non-treated ones following either
ntravenous or intramuscular injections of oxytetracycline long-acting formulation.
~ significant decreament in the activities of AST and AL T was observed in serum
amples following intravenous and intramuscular injection of oxytetracycline long-
cting formulation in non-treated and diminazene pre-treated goats compared with
alues recorded before injection. Calcium and phosphorus values were significantly
ecreased with fluctuated values in both tested groups as compared with pre-
ijection values following either intravenous or intramuscular injection of xytetracycline long-acting formulation.