الفهرس 
AtopyOnly 14 pages are availabe for public view
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Abstract
Atopy is an inherited predisposition to produce immunoglobulin E (IgE) antibodies manifesting clinically as atopic dermatitis, bronchial asthma, urticaria or allergic rhinitis.
Although the primary site of involvement in inflammatory bowel diseases (IBDs) is the bowel, a variety of extra-intestinal manifestations (EIMs) have been reported in patients with IBDs. Atopy could be considered one of these extraintestinal manifestations. Several explanations for this phenomenon have been given over years; however, no definite conclusions have been reached.
The aim of our study was to investigate the prevalence of atopic manifestations in patients with IBD and evaluate their clinical features.
Our study was conducted on two groups;
Group A: Sixty newly diagnosed naïve IBD patients; fifty one patients had UC and nine patients had CD confirmed by colonoscopy and histopathological examination.
Group B: Another sixty demographically matched individuals (free from any gastrointestinal symptoms) as a control group.
Pulmonary symptoms were more detected in group A when compared to group B with statistically significant difference.
On comparing symptoms and signs of allergic diseases in both groups, we found statistically higher prevalence of allergic symptoms among group A while no statistically significant difference as regard signs. On taking detailed history of allergic symptoms there was no statistically significant difference as regard each entity, though symptoms of asthma (recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning, occur or worsen in a seasonal pattern, often reversible either spontaneously or with treatment) did have a trend to be high in group A.
Both past and family history of atopy found to be more positive in group A when compared to group B with statistically significant difference.
The results of this study also revealed that blood eosinophilia and pulmonary function test abnormalities were more frequent in group A than in group B with statistically significant difference.
Skin prick test reactivity to both food allergens namely; aspirin and egg as well as inhalant allergens namely; house dust and mixed moulds were found to be more in group A than group B with statistically significant difference.
Two other tests for atopy were performed in the current study namely; serum total IgE and PIT to various allergens; both showed positive results which were more in group A patients when compared to group B with statistically high significant difference.
No statistically significant relation was found between the different parameters of atopy (skin prick test, serum total IgE, PIT) and the duration of intestinal disease in group A.
The study also revealed no statistically significant relation between different parameters of atopy and the type of IBD (whether UC or CD), histological activity index, clinical activity index or presence of extraintestinal manifestations.
from our study, we concluded the following;
Atopic manifestations are more in patients with IBD. This was proved by history of allergic symptoms, past and family history of allergy, skin prick test and serum total IgE. No significant relation was found between atopy and the type of IBD whether UC or CD, the histological activity index, the clinical activity index or the extraintestinal manifestations./